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Apex Nursing

Reference — Infection Control

Infection Control Reference

Infection prevention is a core nursing competency. The CDC's precaution tiers — standard precautions plus transmission-based precautions — form the foundation of healthcare-associated infection (HAI) prevention.

Educational use only. Always follow your facility's infection control policy. PPE requirements may differ by institution, patient condition, and current public health guidance. Consult infection control when in doubt. This material supports nursing education and exam review. It is not medical advice and is not a substitute for clinical judgment, institutional policy, or medical direction. Always follow facility protocols and current provider orders.

Standard Precautions

Standard precautions apply to every patient, every time — regardless of known diagnosis or infection status. They are based on the principle that all blood, body fluids, secretions, and non-intact skin are potentially infectious.

Components of standard precautions:

  • Hand hygiene — the single most effective infection prevention measure (see hand hygiene section below)
  • Gloves — when touching blood, body fluids, secretions, excretions, non-intact skin, or mucous membranes
  • Gown — when there is risk of contaminating clothing or skin with body fluids
  • Mask and eye protection or face shield — when procedures may generate splashes or sprays of blood or body fluids
  • Safe needle practice — never recap needles two-handed; use safety devices; dispose in puncture-resistant sharps containers
  • Respiratory hygiene / cough etiquette — apply to all patients with signs of respiratory infection from point of entry
  • Safe injection practices — one needle, one syringe, one patient; never share multi-dose vials between patients
  • Environmental cleaning — clean and disinfect patient care equipment and patient environment per facility protocol

Transmission-Based Precautions

Used in addition to standard precautions when a patient has a known or suspected infection requiring additional containment.

Precaution TypeTransmission RoutePPE RequiredRoom Type
ContactDirect or indirect contact with patient or environmentGloves + Gown (on entry)Private room preferred; cohorting if necessary
DropletLarge respiratory droplets (> 5 µm) — within ~3 feetSurgical mask (within 3 ft); gloves + gown per standard precautionsPrivate room preferred; door may remain open
AirborneAirborne particles (≤ 5 µm) — remain suspended in airFit-tested N95 respirator (or higher); gloves + gownNegative-pressure room required; door kept closed

Common Conditions by Precaution Type

PrecautionCommon Examples
ContactMRSA, VRE, C. difficile, RSV, scabies, wound infections with resistant organisms, norovirus (contact + droplet)
DropletInfluenza, COVID-19 (often combined with contact), meningococcal meningitis, pertussis (whooping cough), mumps, rubella, group A strep pharyngitis
AirbornePulmonary tuberculosis (TB), measles (rubeola), varicella (chickenpox), disseminated zoster (shingles) — also contact precautions for zoster

Some organisms require combined precautions. COVID-19 guidance has evolved — follow current facility and CDC recommendations. When in doubt, apply more protective precautions until clarified.

Hand Hygiene

Hand hygiene is the most important infection prevention measure. The WHO “5 Moments for Hand Hygiene” define when hand hygiene is required:

  1. Before touching a patient
  2. Before a clean or aseptic procedure
  3. After body fluid exposure risk
  4. After touching a patient
  5. After touching patient surroundings

Alcohol-based hand rub (ABHR):

  • Preferred method when hands are not visibly soiled
  • Apply to all surfaces of hands and rub until dry (approximately 20–30 seconds)
  • Effective against most healthcare pathogens including MRSA and influenza
  • Not effective against C. difficile spores or norovirus — use soap and water for these

Soap and water:

  • Required when hands are visibly soiled with blood or body fluids
  • Required for C. difficile and norovirus — ABHR does not kill spores
  • Wash for at least 20 seconds; dry thoroughly with a single-use towel
  • Use the towel to turn off the faucet to avoid recontamination

PPE Donning and Doffing Order

Donning (Putting On) Order:

  1. Hand hygiene
  2. Gown (tie at neck and back)
  3. Mask or respirator
  4. Goggles or face shield
  5. Gloves (over gown cuffs)

Doffing (Removing) Order:

  1. Gloves (roll away from body)
  2. Hand hygiene
  3. Goggles or face shield (handle by straps)
  4. Gown (pull away from neck and body)
  5. Hand hygiene
  6. Mask/respirator (handle by straps or ties only)
  7. Hand hygiene

The most contaminated items (gloves, gown front) are removed first to prevent self-contamination. Never touch the front of a used mask — the outside surface is considered contaminated.

Related Resources

Standards & sources

Fact-checked Jun 21, 2026

This page is written to align with CDC / HICPAC · Infectious Diseases Society of America (IDSA) / SHEA. It is an educational summary, not a citation of any single document — always verify specific doses, values, and protocols against current guidelines and your facility policy. How we source content →